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ResearchBlogging.orgI HAVE ALREADY mentioned one type of selfish genetic element. These are mobile elements that can move about and reproduce within the genome, and include the transposon and retrotransposons. A second similar type of selfish genetic element are the homing endonucleases. These come in two forms, as introns which are spliced out of RNA and then translated into protein instead of being discarded, or as inteins that splice out of the protein once it has been synthesized. In both cases the homing endonuclease then during meiosis attacks the allele that does not contain the homing endonuclease intron or intein and triggers DNA repair that duplicates the homing endonuclease’s sequence. Since mobile elements and homing endonucleases either attack at a wide variety of sites or duplicate onto both of a pair of chromosomes, they are passed on according to Mendelian inheritance patterns. But there are other selfish genetic elements that are passed on preferentially, and a new paper in Genetica focuses on the effects of these selfish elements upon fertility in carrier males.

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